Deadliest Enemy: Our War Against Killer Germs is a non-fiction book by epidemiologist Michael T. Osterholm and writer Mark Olshaker, that explores public health emergencies including antimicrobial resistance, emerging infectious disease, and the threat of an influenza pandemic. It proposes a nine-point "battle plan for survival" for dealing with these threats, including solutions to antimicrobial drug resistance.



The book also focuses on the epidemiology of HIV/AIDS, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), toxic shock syndrome, Zika, Ebola, bioterrorism, influenza research, and the antivaccine movement.



The book was first published in March 2017 by Little, Brown and Company.