Two dense, inseparable friends hit the road for their 10-year high school reunion and concoct an elaborate lie about their lives in order to impress their classmates. Romy and Michelle have been through it all including being tortured by the Popular crowd when in high school. When they receive word of a 10 year reunion, they come to realize their lives aren't as impressive as they'd like them to be. Instead of staying home they go to the reunion with business outfits, cell phones, and one heck of a bogus success story.