Make Love! The Bruce Campbell Way begins with an excerpt from an email that Bruce Campbell received from Barry Neville from St. Martin's Press in regard to a book, Walk this Way, that he was attempting to write. The email expresses the publisher's disinterest in that book, but a desire for Campbell to work on a different project. Upon calling Barry Neville, Bruce is presented with the idea of writing a relationship book. Bruce feels he cannot approach the concept, since he does not see himself as an authority on the subject and feels his editor has a false impression of his mastery of relationships.

He is contacted by his acting agent, Barry, about a potential role in a Richard Gere/Renée Zellweger romantic comedy entitled Let's Make Love, written by Kevin Jarre, directed by Mike Nichols and produced by Robert Evans. Bruce jumps to the conclusion that the role is a small, insignificant part, but he finds out that his role is in fact a large part as the wise-cracking doorman. Bruce ends up going to New York and auditioning for the role. Bruce ends up getting the role despite the fact he was not the first, second or last choice; others considered included Johnny Depp, John Cusack, Billy Campbell, Gary Sinise, John Malkovich and Robert Patrick. From this point on, Bruce tries to do research for his role. He first tries being a doorman at the Waldorf-Astoria Hotel, where he has an encounter with Colin Powell that does not end well.