Over the course of one evening, an unsuspecting group of twenty-somethings find themselves bombarded by a series of natural disasters and catastrophic events. Will, Lisa, and two of their friends attempt to flee man-made and natural disasters and encounter Batman, Hancock, The Hulk, Indiana Jones, Hannah Montana, Michael Jackson, Beowulf, the Love Guru, Iron Man, rabid chipmunks amongst others in their seemingly vain efforts to seek help and shelter from unknown threats.