Set in a not-too-distant future where America has lost its "war" on drugs, Fred, an undercover cop, is one of many people hooked on the popular drug, Substance D, which causes its users to develop split personalities. Fred is obsessed with taking down Bob, a notorious drug dealer, but due to his Substance D addiction, he does not know that he is also Bob.

This novel was made into a movie starring Keanu Reeves ("Constantine," "The Matrix" trilogy), Academy Award-nominee and Golden Globe-winner Winona Ryder ("Girl, Interupted," "Mr. Deeds"), Academy Award and Emmy-nominee and Golden Globe-winner Robert Downey Jr. ("Good Night, And Good Luck" "Kiss Kiss, Bang Bang"), and Academy Award and Golden Globe-nominee and Emmy-winner Woody Harrelson ("North Country," "The People vs. Larry Flynt"). Directed by Academy Award-nominee Richard Linklater ("Before Sunset," "Dazed and Confused"). Filmed in live-action, and then animated using the same critically acclaimed process that Linklater used in his previous film, "Waking Life."