In the middle of the night, a controversial U.S. senator is found murdered in bed in his Georgetown pied-a-terre. The police turn up only one clue: a mysterious rhyme signed "Jack and Jill" promising that this is just the beginning. Jack and Jill are out to get the rich and famous, and they will stop at nothing until their fiendish plan is carried out.

Meanwhile, Washington, D. C., homicide detective Alex Cross is called to a murder scene only blocks from his house, far from the corridors of power where he spends his days. The victim: a beautiful little girl, savagely beaten--and desposited in front of the elementary school Cross's son, Damon, attends.