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This book provides a unique, wide-ranging description of the phenomenon of cancer and its pathological effects in diverse species including humans, domesticated and wild animals, invertebrates, and plants. The broad scope of information presented is used to construct radical new insights into biological self-regulation and explain their relevance to its disruption by cancerous growth and spread within the human body.Mechanisms of action of carcinogenic agents, initiation, progression, metastasis, inappropriate gene expression, dormancy, latency, regression, and reasons for susceptibility and/or resistance to cancer are all considered. Also discussed are criteria for pathological diagnosis, advances in treatment, implications for public health, and pitfalls in diagnosis and interpretation of experimental results.
Defining Cancer: Comparisons of Normal Development and Cancer Formation
Understanding the Nature of Cancer–General Principles
The Phenomenon of Inappropriate Gene Expression and Its Biological and Clinical Consequences
The Tumour “System”—Pathology and Pathophysiology of the Tumour Microenvironment
The Tumour System
The Host Stroma and the Tumour Microenvironment
Prevalence of Cancer in Nature and History of Study of the Disease
The Biology and Natural History of Cancer
Major Events in the History of Medical Understanding of Cancer
Causes and Mechanisms of Cancer Formation, Invasion, Metastasis and Associated Symptoms: Clinical and Experimental Studies
The Behaviour of Cancers: Invasion and Metastasis I. Clinico-Pathological Aspects
The Behaviour of Cancers: Invasion and Metastasis II. Experimental Analysis of Mechanisms
Causes of Cancer and Mechanisms of Carcinogenesis
Paraneoplastic Syndromes
Synthesis and Significance of a New Perspective on Malignancy
Clinical Implications of Multi-level (Scalar) Disorganisation in Cancer
Understanding the Significance of Cancer in the Overall Spectrum of Disease