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Constituting the majority of all known compounds, heterocycles are structures that incorporate one or more heteroatoms within their core, thus exhibiting properties that are quite different from their all-carbon analogs. They are fundamental to all fields of chemistry and, therefore, their synthesis and modification has attracted a great deal of attention in the recent years. In this vein, transition-metal-catalyzed C-H bond functionalization forms a crucial tool for generating and analyzing heterocyclic compounds. Transition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume Set, showcases diverse C-H functionalization methodologies and their incorporation into the latest research. The chapters serve as an essential tool depicting detailed site-selective functionalization of heterocyclic cores, along with a comprehensive discussion on their mechanistic approaches. Transition-Metal-Catalyzed C-H Functionalization of Heterocycles, Two-Volume-Set is a valuable guide for students and researchers in organic synthesis and process development, in both academic and industrial contexts.
Volume 1
Historical Perspective and Mechanistic Aspects of C–H Bond Functionalization
Recent Advances in C–H Functionalization of Five–Membered Heterocycles with Single Heteroatoms
Functionalization of Five-membered Heterocycles with Two Heteroatoms
Transition Metal-Catalyzed C–H Functionalization of Indole Benzenoid Ring
Transition Metal-Catalyzed C2 and C3 Functionalization of Indoles
C(sp2)–H Functionalization of Indolines at the C7-Position
Transition Metal-Catalyzed C–H Functionalization of Benzofused Azoles with Two or More Heteroatoms
Volume 2
Functionalization of Pyridines, Quinolines, and Isoquinolines
Transition Metal-catalyzed C-H Bond Functionalization of Diazines and Their Benzo Derivatives
Functionalization of Chromenes and Their Derivatives
Transition Metal-Catalyzed C–H Functionalization of Imidazo-fused Heterocycles
Dehydrogenative Annulation of Heterocycles: Synthesis of Fused Heterocycles
C–H Functionalization of Saturated Heterocycles Beyond the C2 Position
Asymmetric Functionalization of C–H Bonds in Heterocycles
Transition Metal-Catalyzed C–H Functionalization of Nucleoside Bases
C–H Activation for the Synthesis of C1-(hetero)aryl Glycosides
Late-stage C–H Functionalization: Synthesis of Natural Products and Pharmaceuticals
Late-stage Functionalization of Pharmaceuticals, Agrochemicals, and Natural Products