Sandeep Balakrishnan is a restaurant owner in Kochi who underwent heart transplant surgery. Col. Ravindran was the one from whom Sandeep received the heart, and during his post-surgery recovery phase, Ravindran’s daughter Haritha pays him a visit, asking him to be a part of her engagement. What we see in Hridayapoorvam are the events that unfold in the life of Sandeep during that visit to Pune.