In this episode the Waking Up podcast, Sam Harris speaks with Michael Pollan about his new book “How to Change Your Mind.” They cover the the resurgence of interest in psychedelics in clinical practice and end-of-life care, the “betterment of well people,” the relationship between thinking and mental suffering, the differences between psychedelics and meditation, the non-duality of consciousness, the brain’s “default mode network,” their experiences with various psychedelics, and other topics.